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By: Jack Williams

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Wednesday, 12-Sep-2012 12:22 Email | Share | | Bookmark
Study Questions Daily Asthma Meds

An incredible number of patients with asthma may not need for taking their medicine each day after all.

Nearly 25 million people in the United States are afflicted by asthma, and a lot of of which how to use an inhaled corticosteroid (ICS) medicine 2 times per day, each day, to prevent asthma symptoms. Unlike albuterol, a medicine that opens the airways which is used only to treat symptoms or asthma attacks, patients on inhaled corticosteroids are told to work with this medicine even though they may not be having symptoms.

Now, a survey within the Journal on the American Medical Association suggests this twice-a-day medication is probably not needed.
This may be important news for patients suffering from an illness that not only costs billions in health-related dollars, but also leads to missed times of work and school, along with early death.

Researchers from 10 different institutions within the U. S. looked at 342 adults with mild to moderate asthma have been taking inhaled corticosteroids. They randomly put patients into three groups to review the consequence of different medication management approaches.

Members on the first group had their medication adjusted by the physician every six weeks based upon standard clinical guidelines. The second group had its medication adjusted every six weeks based upon connection between a breathing test, and members on the third group adjusted their medication daily based upon their symptoms.

Researchers found that patients within the third group - those that used their inhaled corticosteroids only when that were there symptoms - did as well as the patients who tried it each day. These patients had no difference in lung function and days missed from practice and work, worsening of symptoms, and asthma attacks.
Additionally, they had no difference regarding is named the reactivity of these lung tissue - the factor behind asthma attacks.

Inhaled corticosteroids are believed generally safe; negative effects are usually mild and can include irritation and dryness on the throat along with a higher likelihood of thrush, a candidiasis on the tongue and mouth. A few studies, nevertheless , suggest the potential of more serious, systemic consequences, for instance decreased growth in children, decreased bone density, and suppression on the immunity mechanism. The jury remains from these effects, though, and these problems could be more likely connected to incorrect reliance on the drugs.
Experts not mixed up in study said the findings are very important.

“This is rather surprising and also provocative data for the reason that this indicates to exhibit that ‘less may be the same’ within the remedying of some patients with persistent asthma, ” said Doctor Clifford Bassett, an allergist and immunologist at NYU Langone Clinic.

Bassett added that although inhaled corticosteroids are extremely safe drugs, decreasing their use might have major cost benefits.

But physicians also warn that asthma patients - or parents of children with asthma - ought not to do something about these findings without discussing with their doctors.

Doctor Andrew Ting, a pediatric pulmonologist at Mount Sinai Clinic, said he feared that some parents might think this means that they could stop giving their children inhaled corticosteroids each day - while in younger patients a day-to-day dose remains believed to be required to keep asthma from increasing.

“I’m concerned it might be misinterpreted within the pediatric population, ” he said, explaining that children alter from adults in the way asthma affects their lungs.

And Bassett told me for all patients, more data should be applied before doctors can produce a formal recommendation.

“This is one study, we should instead get more info along with clinical data to support this enhancements made on regimen, ” he said.

Wednesday, 1-Aug-2012 03:23 Email | Share | | Bookmark
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